Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis.

Journal of neuroimmunology - 1 Oct 2007

van Veen Tineke, Nielsen Jessica, Berkhof Johannes, Barkhof Frederik, Kamphorst Wouter, Bö Lars, Ravid Rivka, Verweij Cor L, Huitinga Inge, Polman Chris H, Uitdehaag Bernard M J

Abstract excerpt

Chemokines mediate selective recruitment of leukocyte subsets into the CNS during inflammatory episodes. We hypothesised that functional polymorphisms in CCR5 and CCL5 influence perivascular leukocyte infiltration, inflammation, axonal loss, and remyelination, and disease course. Therefore, we determined genotypes at four possibly functional polymorphisms in CCR5 and CCL5 for 637 patients and 92 brain donors with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Chemokine CCL5

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemotaxis, Leukocyte

Share to Multiple Sclerosis

Share to Myelin Sheath

Share to Predictive Value of Tests

Share to Radiography

Share to Receptors, CCR5

Source

Identifiers

PMID: 17884183
DOI: 10.1016/j.jneuroim.2007.08.005

Genes

CCL5
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CCL5 and CCR5 genotypes modify clinical, radiological and pathological features of multiple sclerosis.PMID 17884183Read ↗

CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis.Semantic proximity Read ↗

Genetic polymorphisms associated with the development and clinical course of multiple sclerosis (Review)Semantic proximity Read ↗

CCR5Δ32 - A piece of protection in the inflammatory puzzle of multiple sclerosis susceptibility.Semantic proximity Read ↗

Molecular sequencing and phenotyping study of chemokines CCL2, CCL5, and CXCL10 in patients with neuroinflammation multiple sclerosis.Semantic proximity Read ↗

Chemokine polymorphisms: candidates for MS susceptibility and disease course.Semantic proximity Read ↗

Increase in CCR5 Delta32/Delta32 genotype in multiple sclerosis.Semantic proximity Read ↗

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.Semantic proximity Read ↗

Genetic model of MS severity predicts future accumulation of disabilitySemantic proximity Read ↗

A mutated CCR5 gene may have favorable prognostic implications in MS.Semantic proximity Read ↗

CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis.Semantic proximity Read ↗

Immune-Related Gene Variants as Modifiers of Multiple Sclerosis Severity.Semantic proximity Read ↗

Disease severity in Danish multiple sclerosis patients evaluated by MRI and three genetic markers (HLA-DRB1*1501, CCR5 deletion mutation, apolipoprotein E).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.