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Article

CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2024

Tournier Benjamin B, Sorce Silvia, Marteyn Antoine, Ghidoni Roberta, Benussi Luisa, Binetti Giuliano, Herrmann François R, Krause Karl-Heinz, Zekry Dina

Abstract excerpt

INTRODUCTION: As the chemokine receptor5 (CCR5) may play a role in ischemia, we studied the links between CCR5 deficiency, the sensitivity of neurons to oxidative stress, and the development of dementia. METHODS: Logistic regression models with CCR5/apolipoprotein E (ApoE) polymorphisms were applied on a sample of 205 cognitively normal individuals and 189 dementia patients from Geneva. The impact of oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37489764
DOI: 10.1002/alz.13392
PMCID: PMC10917026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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