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Article

Dual effect of C-C motif chemokine receptor 5 on ischemic stroke: More harm than benefit?

European journal of pharmacology - 15 Aug 2023

Jing Kai, Chen Feng, Shi Xiaofei, Guo Jinmin, Liu Xia

Abstract excerpt

Ischemic stroke involves a series of complex pathological mechanisms, of which neuroinflammation is currently the most widely recognized. C-C motif chemokine receptor 5 (CCR5) has recently been shown to be upregulated after cerebral ischemia. Notably, CCR5 is not only involved in neuroinflammation, but also in the blood-brain barrier, neural structures, and connections. Accumulating experimental studies indicate...

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PMID: 37321471
DOI: 10.1016/j.ejphar.2023.175857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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