Article

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

2022-05-19

Abstract excerpt

Multiple studies have recognized the involvement of the complement cascade during Alzheimer’s disease pathogenesis; however, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear. Furthermore, its potential as a therapeutic target to treat AD still remains to be elucidated. Canonically, generation of the anaphylatoxin C5a as the result of complement activa...

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Literature Corpus work: ee007533-145f-52f6-b662-1ded2318afa7
DOI: 10.1101/2022.05.18.492363

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