Article

Efficient Assembly and Verification of ZFNs and TALENs for Modifying Porcine <i>ApoE</i> gene

2015-01-13

Abstract excerpt

Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) are powerful tools for genome engineering. These synthetic nucleases are assembled with programmable, sequence-specific DNA-binding domain and a non-specific FokI cleavage domain. Apolipoprotein E ( ApoE ) gene polymorphism is associated with cardiovascular outcomes, including ischaemic stroke and coronary heart disease (CHD...

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Identifiers and source

Literature Corpus work: 120530fd-b807-51e6-bca1-6b029ec82bbe
DOI: 10.1101/013714

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