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Article

Efficient TALEN-mediated gene knockout in livestock.

Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2012

Carlson Daniel F, Tan Wenfang, Lillico Simon G, Stverakova Dana, Proudfoot Chris, Christian Michelle, Voytas Daniel F, Long Charles R, Whitelaw C Bruce A, Fahrenkrug Scott C

Abstract excerpt

Transcription activator-like effector nucleases (TALENs) are programmable nucleases that join FokI endonuclease with the modular DNA-binding domain of TALEs. Although zinc-finger nucleases enable a variety of genome modifications, their application to genetic engineering of livestock has been slowed by technical limitations of embryo-injection, culture of primary cells, and difficulty in producing reliable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23027955
DOI: 10.1073/pnas.1211446109
PMCID: PMC3491456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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