Article

<i>O</i> -GlcNAcylation reduces phase separation and aggregation of the EWS N-terminal low complexity region

2021-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Many membraneless organelles are thought to be biomolecular condensates formed by phase separation of proteins and other biopolymers. Post-translational modifications (PTMs) can impact protein phase separation behavior, although for many PTMs this aspect of their function is unknown. O -linked β-D- N -acetylglucosaminylation ( O -GlcNAcylation) is an abundant form of intracellular glyco...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82a937b8-0a9f-5a02-a579-a482bc2ba7ef
DOI: 10.1101/2021.05.11.443654

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>O</i> -GlcNAcylation reduces phase separation and aggregation of the EWS N-terminal low complexity regionDOI 10.1101/2021.05.11.443654Read

Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferaseSemantic proximity Read

Aberrant phase separation and cancer.Semantic proximity Read

Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4Semantic proximity Read

Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers.Semantic proximity Read

Mapping high resolution, multidimensional phase diagrams of physiological protein condensatesSemantic proximity Read

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separationSemantic proximity Read

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separationSemantic proximity Read

The role of N-terminal acetylation on biomolecular condensationSemantic proximity Read

DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS CondensatesSemantic proximity Read

Concentration and dosage sensitivity of proteins driving liquid-liquid phase separationSemantic proximity Read

Liquid-liquid phase separation and aggregation of a globular folded protein SUMO1Semantic proximity Read

Liquid-liquid phase separation and amyloid aggregation in the 14-3-3 protein familySemantic proximity Read