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A Spectrophotometric Turbidity Assay to Study Liquid-Liquid Phase Separation of UBQLN2 In Vitro.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Raymond-Smiedy Peter, Bucknor Barrington, Yang Yiran, Zheng Tongyin, Castañeda Carlos A

Abstract excerpt

Liquid-liquid phase separation (LLPS) is hypothesized to be the underlying mechanism for how membraneless organelles or biomolecular condensates form inside both prokaryotic and eukaryotic cells. Protein LLPS is a biophysical process during which proteins demix from homogeneous solution to form protein-dense droplets with liquid-like properties. Disruptions to LLPS, such as changes to material properties of...

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PMID: 36310223
DOI: 10.1007/978-1-0716-2597-2_32

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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