Article

ALS-linked mutations impair UBQLN2 stress-induced biomolecular condensate assembly in cells

2020-10-18

Abstract excerpt

Mutations in Ubiquilin-2 (UBQLN2), a ubiquitin-binding shuttle protein involved in several protein quality control processes, can lead to amyotrophic lateral sclerosis (ALS). We previously found that wild-type UBQLN2 forms dynamic, membraneless biomolecular condensates upon cellular stress, and undergoes liquid-liquid phase separation in vitro . However, the impact of ALS-linked mutations on UBQLN2 condensate for...

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Literature Corpus work: 0f944fe1-ed4a-5720-bad4-6ce823085b07
DOI: 10.1101/2020.10.17.335380

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