Article
Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation.
Epilepsia - 1 Jul 2009
Barnwell L Forbes S, Lugo Joaquin N, Lee Wai L, Willis Sarah E, Gertz Shira J, Hrachovy Richard A, Anderson Anne E
Abstract excerpt
PURPOSE: Kv4.2 subunits contribute to the pore-forming region of channels that express a transient, A-type K(+) current (A-current) in hippocampal CA1 pyramidal cell dendrites. Here, the A-current plays an important role in signal processing and synaptic integration. Kv4.2 knockout mice show a ne...
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