Article

Controlling for Human Population Stratification in Rare Variant Association Studies

2020-02-28

Abstract excerpt

Population stratification is a strong confounding factor in human genetic association studies. In analyses of rare variants, the main correction strategies based on principal components (PC) and linear mixed models (LMM), may yield conflicting conclusions, due to both the specific type of structure induced by rare variants and the particular statistical features of association tests. Studies evaluating these appro...

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Literature Corpus work: 11ee416e-82cd-5719-aba6-54ec14c5837f
DOI: 10.1101/2020.02.28.969477

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