Article
Rare and low frequency variant stratification in the UK population: description and impact on association tests.
PloS one - 1 Jan 2012
Babron Marie-Claude, de Tayrac Marie, Rutledge Douglas N, Zeggini Eleftheria, Génin Emmanuelle
Abstract excerpt
Although variations in allele frequencies at common SNPs have been extensively studied in different populations, little is known about the stratification of rare variants and its impact on association tests. In this paper, we used Affymetrix 500K genotype data from the WTCCC to investigate if variants in three different frequency categories (below 1%, between 1 and 5%, above 5%) show different stratification...
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