Article
Population Stratification in Genetic Association Studies.
Current protocols in human genetics - 18 Oct 2017
Hellwege Jacklyn N, Keaton Jacob M, Giri Ayush, Gao Xiaoyi, Velez Edwards Digna R, Edwards Todd L
Abstract excerpt
Population stratification (PS) is a primary consideration in studies of genetic determinants of human traits. Failure to control for PS may lead to confounding, causing a study to fail for lack of significant results, or resources to be wasted following false-positive signals. Here, historical and current approaches for addressing PS when performing genetic association studies in human populations are reviewed....
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