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Article

Controlling for human population stratification in rare variant association studies.

Scientific reports - 24 Sept 2021

Bouaziz Matthieu, Mullaert Jimmy, Bigio Benedetta, Seeleuthner Yoann, Casanova Jean-Laurent, Alcais Alexandre, Abel Laurent, Cobat Aurélie

Abstract excerpt

Population stratification is a confounder of genetic association studies. In analyses of rare variants, corrections based on principal components (PCs) and linear mixed models (LMMs) yield conflicting conclusions. Studies evaluating these approaches generally focused on limited types of structure and large sample sizes. We investigated the properties of several correction methods through a large simulation study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34561511
DOI: 10.1038/s41598-021-98370-5
PMCID: PMC8463695

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