Article

Mutational signatures in upper tract urothelial carcinoma define etiologically distinct subtypes with prognostic relevance

2019-08-15

Abstract excerpt

Parts of East Asia have a very high upper tract urothelial carcinoma (UTUC) prevalence, and an etiological link between the medicinal use of herbs containing aristolochic acid (AA) and UTUC has been established. The mutational signature of AA, which is characterized by a particular pattern of A:T to T:A transversions, can be detected by genome sequencing. Thus, integrating mutational signatures analysis with clini...

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Literature Corpus work: 11c06643-c994-524f-bbfd-87b47e65293e
DOI: 10.1101/735324

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