Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid

18 Nov 2014

Abstract excerpt

Aristolochic acid (AA) is a potent dietary cytotoxin and carcinogen, and an established etiological agent underlying severe human nephropathies and associated upper urinary tract urothelial cancers, collectively designated aristolochic acid nephropathy (AAN). Its genome-wide mutational signature, marked by predominant A:T > T:A transversions occurring in the 5'-CpApG-3' trinucleotide context and enriched on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug-Induced Hepatotoxicity and Protection
Share to Nephrotoxicity and Medicinal Plants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25403517
DOI: 10.1002/ijc.29338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acidPMID 25403517Read ↗

Mutational signature of aristolochic acid: Clue to the recognition of a global disease.Semantic proximity Read ↗

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.Semantic proximity Read ↗

Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing.Semantic proximity Read ↗

Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure.Semantic proximity Read ↗

Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia.Semantic proximity Read ↗

Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma.Semantic proximity Read ↗

Aristolochic Acid in the Etiology of Renal Cell Carcinoma.Semantic proximity Read ↗

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease.Semantic proximity Read ↗

DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial CancerSemantic proximity Read ↗

Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models.Semantic proximity Read ↗

Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA AdductomicsSemantic proximity Read ↗

Mutation signatures implicate aristolochic acid in bladder cancer developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.