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Article

Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure.

International journal of cancer - 15 Jan 2022

Karanović Sandra, Ardin Maude, Tang Zuojian, Tomić Karla, Villar Stephanie, Renard Claire, Venturini Elisa, Lorch Adam H, Lee Daniel S, Stipančić Želimir, Slade Neda, Vuković Brinar Ivana, Dittrich Damir, Karlović Krešimir, Borovečki Fran, Dickman Kathleen G, Olivier Magali, Grollman Arthur P, Jelaković Bojan, Zavadil Jiri

Abstract excerpt

Recurrent upper tract urothelial carcinomas (UTUCs) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe. We applied an integrative multiomics analysis of UTUCs, corresponding unaffected tissues and of...

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Identifiers

PMID: 34569060
DOI: 10.1002/ijc.33827
PMCID: PMC8627473

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