Article
Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing.
Science translational medicine - 7 Aug 2013
Hoang Margaret L, Chen Chung-Hsin, Sidorenko Viktoriya S, He Jian, Dickman Kathleen G, Yun Byeong Hwa, Moriya Masaaki, Niknafs Noushin, Douville Christopher, Karchin Rachel, Turesky Robert J, Pu Yeong-Shiau, Vogelstein Bert, Papadopoulos Nickolas, Grollman Arthur P, Kinzler Kenneth W, Rosenquist Thomas A
Abstract excerpt
In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with documented exposure to AA revealed a remarkably large number of somatic mutations and an unusual mutational signature attribu...
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