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Article

Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma.

Theranostics - 1 Jan 2020

Lu Huan, Liang Yuan, Guan Bao, Shi Yue, Gong Yanqing, Li Juan, Kong Wenwen, Liu Jin, Fang Dong, Liu Libo, He Qun, Shakeel Muhammad, Li Xuesong, Zhou Liqun, Ci Weimin

Abstract excerpt

Rationale: Dietary exposure to aristolochic acids and similar compounds (collectively, AA) is a significant risk factor for nephropathy and subsequent upper tract urothelial carcinoma (UTUC). East Asian populations, who have a high prevalence of UTUC, have an unusual genome-wide AA-induced mutational pattern (COSMIC signature 22). Integrating mutational signature analysis with clinicopathological information may...

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PMID: 32292497
DOI: 10.7150/thno.43251
PMCID: PMC7150494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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