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Article

Mutation signatures implicate aristolochic acid in bladder cancer development

27 Apr 2015

Abstract excerpt

BACKGROUND: Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to bladder cancer. METHODS: Here, we investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26015808
DOI: 10.1186/s13073-015-0161-3

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