Article

Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma

2025-10-24

Abstract excerpt

Resistance to targeted therapies develops in the majority of patients, with numerous different mechanisms having been documented. This is frequently linked to intra-tumour heterogeneity and cancer cells transitioning into different states. In this study, we demonstrate cooperativity between co-occurring resistant states in a single tumour. Using BRAF mutant melanoma as a paradigm, we generate three different resis...

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Identifiers and source

Literature Corpus work: 4e17816e-99ec-50fd-8411-de843e9fa8dd
DOI: 10.1101/2025.10.23.684170

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