Article

Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols

2024-08-21

Abstract excerpt

Lentiviral vector-transduced T-cells were approved by the FDA as gene therapy anti-cancer medications. Little is known about the host genetic variation effects on the safety and efficacy of the lentiviral vector gene delivery system. To narrow this knowledge-gap, we characterized hepatic gene delivery by lentiviral vectors across the Collaborative Cross (CC) mouse genetic reference population. For 24 weeks, we per...

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Literature Corpus work: 119ebdaf-42ed-505d-b1bf-a960a85dfab5
DOI: 10.1101/2024.08.20.608805

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