The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.

doi:10.1038/mt.2012.224

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Article

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2013

Nowrouzi Ali, Cheung Wing T, Li Tingting, Zhang Xuegong, Arens Anne, Paruzynski Anna, Waddington Simon N, Osejindu Emma, Reja Safia, von Kalle Christof, Wang Yoahe, Al-Allaf Faisal, Gregory Lisa, Themis Matthew, Holder Maxine, Dighe Niraja, Ruthe Alaine, Buckley Suzanne Mk, Bigger Brian, Montini Eugenio, Thrasher Adrian J, Andrews Robert, Roberts Terry P, Newbold Robert F, Coutelle Charles, Schmidt Manfred, Themis Mike

Abstract excerpt

Genotoxicity models are extremely important to assess retroviral vector biosafety before gene therapy. We have developed an in utero model that demonstrates that hepatocellular carcinoma (HCC) development is restricted to mice receiving nonprimate (np) lentiviral vectors (LV) and does not occur when a primate (p) LV is used regardless of woodchuck post-translation regulatory element (WPRE) mutations to prevent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23299800
DOI: 10.1038/mt.2012.224
PMCID: PMC3594025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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