Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice.

doi:10.1097/HEP.0000000000000547

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Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice.

Hepatology (Baltimore, Md.) - 1 Jan 2024

Brown Ariane J, Won John J, Wolfisberg Raphael, Fahnøe Ulrik, Catanzaro Nicholas, West Ande, Moreira Fernando R, Nogueira Batista Mariana, Ferris Martin T, Linnertz Colton L, Leist Sarah R, Nguyen Cameron, De la Cruz Gabriela, Midkiff Bentley R, Xia Yongjuan, Evangelista Mia D, Montgomery Stephanie A, Billerbeck Eva, Bukh Jens, Scheel Troels K H, Rice Charles M, Sheahan Timothy P

Abstract excerpt

BACKGROUND AIMS: Human genetic variation is thought to guide the outcome of HCV infection, but model systems within which to dissect these host genetic mechanisms are limited. Norway rat hepacivirus, closely related to HCV, causes chronic liver infection in rats but causes acute self-limiting hepatitis in typical strains of laboratory mice, which resolves in 2 weeks. The Collaborative Cross (CC) is a robust mouse...

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PMID: 37540195
DOI: 10.1097/HEP.0000000000000547
PMCID: PMC10718216

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