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Article

Strain-based genetic differences regulate the efficiency of systemic gene delivery as well as expression.

The Journal of biological chemistry - 15 Feb 2002

Liu Yong, Liggitt H Denny, Dow Steven, Handumrongkul Chakkrapong, Heath Timothy D, Debs Robert J

Abstract excerpt

We have characterized the impact of strain-based genetic differences on the efficiency of the intravenous cationic liposome-DNA complex (CLDC)-based gene transfer and expression in mice. We also investigated what steps in the gene delivery and expression pathway appeared responsible for these strain-related differences and whether such differences could be compensated for either by agents that alter host pathways...

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PMID: 11733533
DOI: 10.1074/jbc.M110285200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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