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BMI inadequately mediates the relationship between polygenic risk of adiposity and early onset type 2 diabetes in south Asians

2025-06-12

Abstract excerpt

<h4>Aims</h4> We investigated the relationship between polygenic score (PGS) for BMI and other adiposity PGS with age at type 2 diabetes onset in white European (EUR) and south Asian (SAS) ancestries, and the mediating role of BMI. <h4>Methods</h4> In this retrospective study, using polygenic score (PGS) for BMI, clinically measured BMI and age at type 2 diabetes onset, we conducted mediation analysis separately f...

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Literature Corpus work
118f13bd-38b3-5d0c-81d5-785d38fdeea4
DOI
10.1101/2025.06.12.25329480
Open publication

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BMI inadequately mediates the relationship between polygenic risk of adiposity and early onset type 2 diabetes in south AsiansDOI 10.1101/2025.06.12.25329480
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