Article
Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.
Communications biology - 7 Apr 2022
Loh Marie, Zhang Weihua, Ng Hong Kiat, Schmid Katharina, Lamri Amel, Tong Lin, Ahmad Meraj, Lee Jung-Jin, Ng Maggie C Y, Petty Lauren E, Spracklen Cassandra N, Takeuchi Fumihiko, Islam Md Tariqul, Jasmine Farzana, Kasturiratne Anuradhani, Kibriya Muhammad, Mohlke Karen L, Paré Guillaume, Prasad Gauri, Shahriar Mohammad, Chee Miao Ling, de Silva H Janaka, Engert James C, Gerstein Hertzel C, Mani K Radha, Sabanayagam Charumathi, Vujkovic Marijana, Wickremasinghe Ananda R, Wong Tien Yin, Yajnik Chittaranjan S, Yusuf Salim, Ahsan Habibul, Bharadwaj Dwaipayan, Anand Sonia S, Below Jennifer E, Boehnke Michael, Bowden Donald W, Chandak Giriraj R, Cheng Ching-Yu, Kato Norihiro, Mahajan Anubha, Sim Xueling, McCarthy Mark I, Morris Andrew P, Kooner Jaspal S, Saleheen Danish, Chambers John C
Abstract excerpt
South Asians are at high risk of developing type 2 diabetes (T2D). We carried out a genome-wide association meta-analysis with South Asian T2D cases (n = 16,677) and controls (n = 33,856), followed by combined analyses with Europeans (neff = 231,420). We identify 21 novel genetic loci for significant association with T2D (P = 4.7 × 10-8 to 5.2 × 10-12), to the best of our knowledge at the point of analysis. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.