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Article

Ancestry specific polygenic risk score, dietary patterns, physical activity and incident type 2 diabetes.

Human genomics - 8 Jul 2026

Hardy Dale S, Garvin Jane T, Leak-Johnson Tennille S, Mersha Tesfaye B

Abstract excerpt

BACKGROUND: It is unknown whether the impact of lifestyle could mitigate the genetically driven high-risk polygenic risk score (PRS) in different ancestries. OBJECTIVES: We determined associations and interactions between high-risk PRS, dietary patterns, physical activity, and metabolic burden and their impact on incident type 2 diabetes mellitus (T2DM) in European Americans and African Americans. A secondary aim...

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Identifiers

PMID: 42415203
DOI: 10.1186/s40246-025-00900-z
PMCID: PMC13343712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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