Article

Multi-omics analysis identifies BICC1+ fibroblasts drive triple negative breast cancer aggressiveness and poor prognosis

2026-06-19

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Triple negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) promote immunosuppression and drug resistance. This study identifies a specific fibroblast subpopulation driving TNBC progression. <bold>Methods</bold> We performed bulk, spatial transcriptomics (ST), sin...

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Literature Corpus work: b2bfb496-da94-547a-88a8-1b25d29aa5f6
DOI: 10.21203/rs.3.rs-9487369/v1

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