Article

Mechanical force sensing drives extrusion of Enterovirus A71-infected cells from colonic epithelial organoids

2022-08-15

Abstract excerpt

<title>Abstract</title> <p>Enterovirus A71 (EV-A71) causes severe disease upon systemic infection, sometimes leading to life-threatening neurological dysfunction. In most cases, infection is limited to the gastrointestinal tract, where virus is amplified for transmission. We used three-dimensional epithelial organoids generated from crypt stem cells of healthy patient colon tissue (colonoids) to investigate viral...

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Literature Corpus work: 118515e3-3d20-5bd1-93a6-b90c864fa7a1
DOI: 10.21203/rs.3.rs-1915730/v1

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