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Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus

15 Feb 2021

Abstract excerpt

Enteroviruses, such as EV-A71 and CVA16, mainly infect the human gastrointestinal tract. Human coronaviruses, including SARS-CoV and SARS-CoV-2, have been variably associated with gastrointestinal symptoms. We aimed to optimize the human intestinal organoids and hypothesize that these optimized intestinal organoids can recapitulate enteric infections of enterovirus and coronavirus. We demonstrate that the...

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PMID: 33626333
DOI: 10.1016/j.stemcr.2021.02.009

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