Senecavirus a can replicate in apical-out porcine intestinal organoids and induce stress granules and innate immune response

Abstract excerpt

Senecavirus A (SVA) causes clinical blistering and ulcerative lesions resembling foot-and-mouth disease (FMD), often with mixed infections that exacerbate the disease and impact pig industry development. SVA has been demonstrated to induce diarrhea, dehydration and mortality in piglets. However, the underlying mechanisms of SVA-related intestinal infections remain underexplored. In this study, a three-dimensional...

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