Human Assembloid Model of Emergent Neurotropic Enteroviruses

Abstract excerpt

Enteroviruses (EVs) are the leading cause of viral meningitis in children. Recent outbreaks of non-polio EVs, most notably EV-A71 and EV-D68, have been associated with a polio-like paralysis known as acute flaccid myelitis (AFM). The lack of relevant models that mimic the cellular and functional responses of these human-restricted pathogens has hampered the development of effective treatments. We have previously e...

Topics

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• Capsid Proteins
• Enterovirus Infections
• Mice
• Mutation
• Neurogenetic and Muscular Disorders Research
• Neuromuscular Diseases
• RNA Research and Splicing
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

7be97845-fc25-54de-8ac0-6f075494533f

DOI

10.1101/2025.11.18.689148