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Article

Mechanosensitive extrusion of Enterovirus A71-infected cells from colonic organoids

13 Mar 2023

Abstract excerpt

Enterovirus A71 causes severe disease upon systemic infection, sometimes leading to life-threatening neurological dysfunction. However, in most cases infection is asymptomatic and limited to the gastrointestinal tract, where virus is amplified for transmission. Picornaviruses have previously been shown to exit infected cells via either cell lysis or secretion of vesicles. Here we report that entire Enterovirus...

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PMID: 36914754
DOI: 10.1038/s41564-023-01339-5

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