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The mouse gcd2 mutation causes primordial germ cell depletion.

Mechanisms of development - 1 Jul 2006

Reinholdt Laura G, Munroe Robert J, Kamdar Sonja, Schimenti John C

Abstract excerpt

Germ cell depletion 2 (gcd2) is a chemically induced recessive mutation that causes infertility in male and female mice. The infertility is caused by germ cell depletion as early as 11.5 days post-coitum, when primordial germ cells have completed their migration to the embryonic gonads. Thus, the gcd2 mutation affects the proliferation and/or survival of germ cells after they arrive in the embryonic gonad, a...

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PMID: 16822657
DOI: 10.1016/j.mod.2006.05.003

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