Article

Primordial germ cell DNA demethylation and development require DNA translesion synthesis.

2023-07-06

Abstract excerpt

<title>Abstract</title> <p>Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. It remains unclear if the role of DDR is solely in meiosis. One pathway implicated in human fertility is DNA translesion synthesis (TLS), which allows replication impediments to be bypassed. We find that TLS is essential for pre-meiotic germ cell development i...

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Literature Corpus work: 6fa19d73-cc2b-5c21-8159-4080da82eadc
DOI: 10.21203/rs.3.rs-3005183/v1

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