Article
Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes.
Scientific reports - 8 Jan 2020
Satoh Yasunari, Asakawa Jun-Ichi, Nishimura Mayumi, Kuo Tony, Shinkai Norio, Cullings Harry M, Minakuchi Yohei, Sese Jun, Toyoda Atsushi, Shimada Yoshiya, Nakamura Nori, Uchimura Arikuni
Abstract excerpt
The exposure of germ cells to radiation introduces mutations in the genomes of offspring, and a previous whole-genome sequencing study indicated that the irradiation of mouse sperm induces insertions/deletions (indels) and multisite mutations (clustered single nucleotide variants and indels). However, the current knowledge on the mutation spectra is limited, and the effects of radiation exposure on germ cells at...
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