Article

Microglia show differential transcriptomic response to Aβ peptide aggregates <i>ex vivo</i> and <i>in vivo</i>

2021-03-03

Abstract excerpt

Aggregation and accumulation of amyloid-β (Aβ) is a defining feature of Alzheimer’s disease (AD) pathology. To study microglial responses to Aβ, we applied exogenous Aβ peptide, in either oligomeric or fibrillar conformation, to primary mouse microglial cultures and evaluated system level transcriptional changes and then compared these to transcriptomic changes in the brains of CRND8 APP mice. We find that primary...

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Literature Corpus work: 11618715-55aa-5a22-9578-e5434266ff00
DOI: 10.1101/2021.03.02.433544

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