Article

Machine Learning-Driven Discovery of a Lipid Nanoparticle for In-Vivo T-Cell Transfection in Non-Human Primates

2025-12-04

Abstract excerpt

<title>Abstract</title> <p>The limited availability of in-vivo transfection of T-cells with mRNA therapeutics remains a major bottleneck in the development of scalable and accessible gene and cell therapies. Lipid nanoparticles (LNPs) offer an in vivo, non-viral alternative to ex-vivo genetic engineering but have historically shown poor performance in T-cells. Our machine learning approach enabled the rapid de...

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Literature Corpus work: 3da8fd0b-32b2-5016-b24c-72425c4a91f7
DOI: 10.21203/rs.3.rs-7848619/v1

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Machine Learning-Driven Discovery of a Lipid Nanoparticle for In-Vivo T-Cell Transfection in Non-Human PrimatesDOI 10.21203/rs.3.rs-7848619/v1Read

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