Article

The TOMM40 ‘523’ polymorphism in disease risk and age of symptom onset in two independent cohorts of Parkinson’s disease.

2020-12-10

Abstract excerpt

Abnormal mitochondrial function is a key process in the pathogenesis of Parkinson’s disease (PD). The central pore-forming protein TOM40 of the mitochondria is encoded by the translocase of outer mitochondrial membrane 40 homologue gene ( TOMM40 ). The highly variant poly-T repeat is associated with age-related cognitive decline and age of onset in Alzheimer’s disease, but whether it plays a role in modifying the...

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Literature Corpus work: 115e25d4-ac78-52be-baf4-8b9dbb0d3b1c
DOI: 10.21203/rs.3.rs-119345/v1

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