Article
TOMM40 and APOE common genetic variants are not Parkinson's disease risk factors.
Neurobiology of aging - 1 Aug 2013
Peplonska Beata, Safranow Krzysztof, Gaweda-Walerych Katarzyna, Maruszak Aleksandra, Czyzewski Krzysztof, Rudzinska Monika, Barcikowska Maria, Zekanowski Cezary
Abstract excerpt
Polymorphic, deoxythymidine-tract in intron 6 of the TOMM40 gene has been associated with Alzheimer's disease. We have investigated the impact of this polymorphism on Parkinson's disease risk and age of onset, independently and in combination with apolipoprotein E alleles, in a group of 407 PD patients and 305 control subjects. No significant association was observed at the single allele, genotype, or haplotype...
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