Article

Neuro-behavioral impact of Tourette-related striatal disinhibition in rats

2025-02-06

Abstract excerpt

Tourette syndrome has been linked to reduced GABAergic inhibition, so called neural disinhibition, in the dorsal striatum. Dorsal-striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A-receptor antagonists, produces striatal local field potential (LFP) spike-wave discharges and tic-like movements resembling motor tics. Here, we characterized further the neuro-behavioral impact of s...

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Literature Corpus work: 114a2c9b-2bd1-51f6-855d-6cb0b8c69ff9
DOI: 10.1101/2025.02.02.636049

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