Article

Thalamo-insular pathway regulates tic generation via motor-limbic crosstalk

2025-08-25

Abstract excerpt

<h4>SUMMARY</h4> Tic disorders accompanied by premonitory urges are hallmark symptoms of Tourette syndrome (TS), yet the underlying neuronal mechanisms remain elusive. Here, we establish a mouse model of motor tics by unilateral striatal injection of a GABA A receptor antagonist. This model induces c-Fos activation in both motor and limbic structures, including the insular cortex (IC). Fiber photometry reveals t...

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Identifiers and source

Literature Corpus work: 9a542326-296c-5b5e-b235-7a1731d04756
DOI: 10.1101/2025.08.24.672034

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