Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats.

Abstract excerpt

Motor tics are sudden, repetitive, involuntary movements representing the hallmark behaviors of the neurodevelopmental disease Tourette's syndrome (TS). The primary cause of TS remains unclear. The initial observation that dopaminergic antagonists alleviate tics led to the development of a dopaminergic theory of TS etiology which is supported by post mortem and in vivo studies indicating that non-physiological...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Corpus Striatum
• Share to Dopamine Agonists
• Share to Haloperidol