Article

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

2022-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Compulsive-like alcohol drinking (CLAD), where intake persists despite adverse consequences, is often a core facet of alcohol use disorder. Recent work sheds light on underlying mechanisms, but much remains unknown about CLAD etiology. Previously, we showed that projections from anterior insula (aINS), a central mediator of emotion, motivation, and interoception, promote CLAD in rodents, and hea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 048e52c1-2133-5c78-9523-d6f49966afa9
DOI: 10.1101/2022.05.24.493243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumptionDOI 10.1101/2022.05.24.493243Read

Proactive Versus Reactive Control Strategies Differentially Mediate Alcohol Drinking in Wistar and P ratsSemantic proximity Read

Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in ratsSemantic proximity Read

Impaired Synaptic Activity in the Basolateral Amygdala Is Associated With an Alcohol Use Disorder-Like Vulnerable Phenotype in Male Rats.Semantic proximity Read

Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum.Semantic proximity Read

Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex.Semantic proximity Read

Compulsive coping behaviour, developed predominantly by sign-trackers, is exacerbated by chronic atomoxetineSemantic proximity Read

A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behaviorSemantic proximity Read

Contrasting adaptations to synaptic physiology of prefrontal cortex interneuron subtypes in a mouse model of binge drinkingSemantic proximity Read

Sex-associated differences in incentive salience and drinking behavior in a rodent model of alcohol relapseSemantic proximity Read

Opioid withdrawal engages a habenular subpopulation responsive to aversive statesSemantic proximity Read

An operant ethanol self-administration paradigm that discriminates between appetitive and consummatory behaviors reveals distinct behavioral phenotypes in commonly used rat strains.Semantic proximity Read

Disrupting astrocyte signalling in the nucleus accumbens impairs incentive-driven instrumental actionsSemantic proximity Read