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High-Resolution Cryo-EM Structure Determination of α-Synuclein – A Prototypical Amyloid Fibril

2024-09-19

Abstract excerpt

The physiological role of α-synuclein (α-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. However, under certain cellular conditions that are not well understood, α-syn will self-assemble into β-sheet rich fibrils that accumulate and form insoluble neuronal inclusions. Studies of patient derived brain...

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Literature Corpus work
11446671-dbfe-5032-b1ee-bf356df9d4d2
DOI
10.1101/2024.09.18.613698
Open publication

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