Article
New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy.
Current opinion in neurobiology - 1 Apr 2020
Guerrero-Ferreira Ricardo, Kovacik Lubomir, Ni Dongchun, Stahlberg Henning
Abstract excerpt
Fibrils of alpha-synuclein are significant components of cellular inclusions associated with several neuropathological disorders including Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. In recent years, technological advances in the field of transmission electron microscopy and image processing have made it possible to solve the structure of alpha-synuclein fibrils at high resolution....
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