Article

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology

2024-11-22

Abstract excerpt

<h4>ABSTRACT</h4> The ordered assembly of α-synuclein protein into filaments encoded by SNCA characterizes neurodegenerative diseases called synucleinopathies. Lewy body disease (LBD) shows predominantly neuronal α-synuclein pathology and multiple system atrophy (MSA) predominantly oligodendrocytic α-synuclein pathology affecting subcortical brain structures. Based on cryo-electron microscopy, it was reported tha...

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Literature Corpus work: 7faf6350-b2b9-5709-9a95-9cd13544b2d5
DOI: 10.1101/2024.11.21.624748

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