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Article

Early developmental asymmetries in cell lineage trees in living individuals

2020-08-25

Abstract excerpt

Post-zygotic mosaic mutations can be used to track cell lineages in humans. By using cell cloning and induced pluripotent cell lines, we analyzed early cell lineages in two living individuals (a patient and a control), and a postmortem human specimen. Of ten reconstructed post-zygotic divisions, none resulted in balanced contributions of daughter lineages to tissues. In both living individuals one of two lineages...

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Identifiers and source

Literature Corpus work
11296fed-7543-5851-844d-aa44a6a333e2
DOI
10.1101/2020.08.24.265751
Open publication

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Early developmental asymmetries in cell lineage trees in living individualsDOI 10.1101/2020.08.24.265751
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