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Article

Early developmental asymmetries in cell lineage trees in living individuals.

Science (New York, N.Y.) - 19 Mar 2021

Fasching Liana, Jang Yeongjun, Tomasi Simone, Schreiner Jeremy, Tomasini Livia, Brady Melanie V, Bae Taejeong, Sarangi Vivekananda, Vasmatzis Nikolaos, Wang Yifan, Szekely Anna, Fernandez Thomas V, Leckman James F, Abyzov Alexej, Vaccarino Flora M

Abstract excerpt

Mosaic mutations can be used to track cell lineages in humans. We used cell cloning to analyze embryonic cell lineages in two living individuals and a postmortem human specimen. Of 10 reconstructed postzygotic divisions, none resulted in balanced contributions of daughter lineages to tissues. In both living individuals, one of two lineages from the first cleavage was dominant across tissues, with 90% frequency in...

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PMID: 33737484
DOI: 10.1126/science.abe0981
PMCID: PMC8324008

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